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El Gran Combo de Puerto Rico, commonly known as El Gran Combo, is a Puerto Rican salsa orchestra based in San Juan, Puerto Rico. Celebrating its 50th anniversary in 2012, it was often considered Puerto Rico's most successful musical group. The group received the moniker La Universidad de la Salsa in Colombia, due to the sheer number of famous salsa musicians and singers who developed their careers with it, who started with the group, or who were occasionally backed up by the band and La India.